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Recombinant Human IL-1RAcP/IL1R3 Protein (Fc & His Tag)
SKU: PKSH032559-50
Recombinant Human IL-1RAcP/IL1R3 Protein (Fc & His Tag)
| SKU # | PKSH032559 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | IL1R, Interleukin-1 Receptor, C3orf, IL-1 Receptor Accessory Protein, IL-1R3, IL-1R-3, IL-1RAcP, Interleukin-1 Receptor 3, Interleukin-1 Receptor Accessory Protein, C3orf13, IL1R3, IL1RAP, FLJ37788, IL 1 receptor accessory protein, IL 1R3, IL 1RAcP, IL 1RAP, Interleukin 1 Accessory Protein, interleukin 1 receptor 3, Interleukin 1 receptor accessory protein |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Ser21-Gln356 |
| Accession | Q9NPH3-2 |
| Calculated Molecular Weight | 66.7 kDa |
| Observed Molecular Weight | 80-100 kDa |
| Tag | C-Fc-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Interleukin-1 Receptor Accessory Protein (IL-1RAcP) is a member of the interleukin-1 receptor family. It contains three Ig-like C2-type domains in the extracellular region and a long cytoplasmic domain implicated in signal transduction. IL-1RAcP acts as a non-ligand binding accessory component of the receptors for IL1α; IL1βand IL33. IL-1RAcP mediates interleukin-1-dependent activation of NF-kappa-B. It is part of the membrane-bound form of the IL-1 receptor. IL-1 RAcP takes part in the Signaling ways by the formation of a ternary complex containing IL1R1; TOLLIP; MYD88; and IRAK1 or IRAK2. In addition; IL-1RAcP modulates the response to interleukins by associating with soluble IL1R1 and enhancing interleukin-binding to the decoy receptor.