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Recombinant Human IL-22BP/IL22RA2 Protein (His Tag)(Active)
SKU: PKSH031300-50
Recombinant Human IL-22BP/IL22RA2 Protein (His Tag)(Active)
| SKU # | PKSH031300 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | UNQ, Il22ra, IL22RA2, UNQ5793, PRO19598, PRO19822, Class II cytokine receptor, CRF2 10, CRF2 S1, CRF2-10, CRF2-S1, CRF2X, Cytokine receptor class II member 10, Cytokine receptor class-II member 10, Cytokine receptor family 2 member 10, Cytokine receptor family type 2, Cytokine receptor family type 2 soluble 1, I22R2, IL 22 receptor subunit alpha 2, IL 22BP, IL 22R alpha 2, IL 22RA2, IL-22 receptor subunit alpha-2, IL22BP, IL-22BP, IL22R alpha 2, IL-22RA2, IL-22R-alpha-2, Interleukin 22 binding protein, Interleukin 22 Receptor alpha 2, Interleukin-22 receptor subunit alpha-2, Interleukin-22-binding protein, MGC150509, MGC150510, soluble 1, ZcytoR16 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Met 1-Pro 231 |
| Accession | NP_851826.1 |
| Calculated Molecular Weight | 26.1 kDa |
| Observed Molecular Weight | 50-55 kDa |
| Tag | C-His |
| Bio-activity | Immobilized IL22BP-His at 10 μg/ml (100 μl/well) can bind biotinylated IL22, The EC50 of biotinylated IL22 is 1.78-4. 14 ng/ml. |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4 Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Interleukin-22 receptor subunit alpha-2 (IL-22RA2); also known as interleukin-22-binding protein (IL-22BP); is a subunit of the receptor for interleukin 22. IL-22BP belongs to the type I I cytokine receptor family and contains 3 fibronectin type-III domains. IL-22BP/IL-22RA2 is expressed in a range of tissues; including those in the digestive; female reproductive; and immune systems. It is expressed in placenta; spleen; breast; skin and lung. It is also detected in intestinal tract; testis; brain; heart and thymus. The dominant cell types expressing IL-22BP/IL-22RA2 were mononuclear cells and epithelium. IL-22BP/IL-22RA2 may play an important role as an IL-22 antagonist in the regulation of inflammatory responses. Interleukin-22 (IL-22) is a member of IL-10 family. It is produced by T cells and induces the production of acute-phase reactants. IL-22 plays important roles in immune response through activation of the STAT 3 signal transduction pathway. Two types of IL-22-binding receptor have been discovered; a membrane-bound receptor and a soluble receptor.