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Recombinant Human IL10RB/IL10R2 Protein (His Tag)
SKU: PKSH033389-50
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Recombinant Human IL10RB/IL10R2 Protein (His Tag)
| SKU # | PKSH033389 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | CRFB, Interleukin-10 receptor subunit, Cytokine receptor class-II member, Cytokine receptor family 2 member, CRF2, IL-10R, CDW210B, CRF2-4, Cytokine receptor class-II member 4, Cytokine receptor family 2 member 4, IL-10R2, Interleukin-10 receptor subunit 2, Interleukin-10 receptor subunit beta(IL10RB), IL10RB, CRFB4, D21S58, D21S66, CRF2-4, IL-10Rb, Cd210, CRF2 4, Cytokine receptor class II, Cytokine receptor class II CRF2 4, Cytokine receptor family II member 4, I10R2, IL-10 receptor subunit beta, IL-10R subunit 2, IL-10R subunit beta, IL10R2, IL-10RB, Interleukin 10 receptor beta, Interleukin-10 receptor subunit beta |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Met20-Ser220 |
| Accession | Q08334 |
| Calculated Molecular Weight | 24.5 kDa |
| Observed Molecular Weight | 48 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
IL10RB is a single- pass type I membrane protein and contains two fibronectin type-III domains. It is an accessory chain which is essential for the active interleukin 10 receptor complex. Coexpression of IL10RB and IL10RA proteins has been shown to be required for IL10-induced signal transduction. Defects in IL10RB are the cause of inflammatory bowel disease type 25 (IBD25) which is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology.