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Recombinant Human IL12RB1 Protein (Fc Tag)
SKU: PKSH033356-50
Recombinant Human IL12RB1 Protein (Fc Tag)
| SKU # | PKSH033356 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | IMD, IL-12R-BETA, IL12RB1, CD212, IL-12R-BETA1, IL12RB, IMD30, IL12R, IL-12Rb1, CD212 antigen, IL-12 receptor beta component, IL-12 receptor subunit beta-1, IL-12R subunit beta-1, IL-12R-beta-1, interleukin-12 receptor beta-1 chain, interleukin-12 receptor subunit beta-1 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Cys24-Glu540 |
| Accession | P42701 |
| Calculated Molecular Weight | 84.2 kDa |
| Observed Molecular Weight | 95-110 kDa |
| Tag | C-Fc |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 90 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 5% trehalose, 5% mannitol, 0.02% Tween 80, pH8.0. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Interleukin12 receptor subunit beta 1 (IL12RB1) is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. IL12RB1 can spontaneously form homodimers and -oligomers; which are able to bind IL12 with only low affinity. IL12 high affinity receptor complex is composed of two subunits designated IL12RB1 and IL12RB2. While IL12RB1 interacts with the IL-12p40 subunit; IL-12p35 is mainly connecting with IL12RB2. This receptor chain is also responsible for transmitting the IL12 signal into the cell. IL12RB1; to the contrary; is also part of the IL23R; where it interacts with the p40 subunit of IL23. IL12RB1 is expressed in activated T cells; NK cells and B cells.