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Recombinant Human IL13RA1 Protein (His Tag)(Active)
SKU: PKSH033390-50
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Recombinant Human IL13RA1 Protein (His Tag)(Active)
| SKU # | PKSH033390 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | CD213A, IL13RA1, CD213A1, CT19, IL-13Ra, NR4, IL13R, IL13RA, IL-13Ra1, alpha 1), bB128O4.2.1 (interleukin 13 receptor, Cancer/testis antigen 19, CD213A1 Antigen, CT 19, I13R1, IL 13 receptor subunit alpha 1, IL 13R alpha 1, IL 13R subunit alpha 1, IL 13Ra, IL 13RA1, IL13 receptor alpha 1 chain, IL-13 receptor subunit alpha-1, IL-13R subunit alpha-1, IL-13R-alpha-1, Interleukin 13 receptor alpha 1, Interleukin 13 receptor alpha 1 chain, interleukin 13 receptor subunit alpha 1, Interleukin-13 receptor subunit alpha-1, NR 4, NR4 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Gly22-Thr343 |
| Accession | P78552 |
| Calculated Molecular Weight | 37.7 kDa |
| Observed Molecular Weight | 55-65 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Interleukin-13 receptor subunit alpha-1(IL13RA1) is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. The human IL13-Rα1 was originally cloned based on sequence homology to the mouse IL13-Rα1, it share 76% aa sequence identity. Human The IL13-Rα1 cDNA encodes a 427 amino acid (aa) residue precursor protein with a putative 21 aa residue signal peptide, a 324 aa residue extracellular domain, a 23 aa residue transmembrane region and a 59 aa residue cytoplasmic tail. The extracellular domain of IL13-Rα1 is also closely related to that of IL13-Rα2. It binds with low affinity to interleukin-13(IL13). IL13RA1 serves as a primary IL13- binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4.