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Recombinant Human IL15RA/IL-15RA Protein (Fc Tag)(Active)
SKU: PKSH032566-50
Recombinant Human IL15RA/IL-15RA Protein (Fc Tag)(Active)
| SKU # | PKSH032566 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | MGC, IL15RA, CD215, alpha, CD215 antigen, IL-15 receptor subunit alpha, IL-15RA, IL-15R-alpha, interleukin 15 receptor, interleukin-15 receptor subunit alpha, MGC104179, AA690181, I15RA, IL 15R alpha, Interleukin 15 receptor alpha, Interleukin 15 receptor subunit alpha, sIL-15 receptor subunit alpha, sIL-15RA, sIL-15R-alpha, Soluble interleukin 15 receptor subunit alpha, Soluble interleukin-15 receptor subunit alpha |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Ile31-Thr172 |
| Accession | Q13261-3 |
| Calculated Molecular Weight | 42.0 kDa |
| Observed Molecular Weight | 60-75 kDa |
| Tag | C-Fc |
| Bio-activity | Measured by its ability to block human IL-15-induced proliferation of CTLL‑2 mouse cytotoxic T cells. The ED50 for this effect is 0.35-3.5 ng/ml. |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Interleukin 15 Receptor alpha (IL-15Rα) is a transmembrane glycoprotein that plays a pleiotropic role in immune development and function, including the positive maintenance of lymphocyte homeostasis. IL-15Rα chain can bind soluble IL-15 and “transpresent” cytokine to the cells, allowing them to respond to IL-15. Soluble IL-15Rα can function as a specific high-affinity IL-15 antagonist. The soluble IL-15/IL-15Rα complexes exhibit a strong agonistic activity which is mediated through membrane-bound IL-15 receptor β and γ heterodimers and enables signaling to cells.