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Recombinant Human IL17RA Protein (His Tag)
SKU: PKSH033629-50
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Recombinant Human IL17RA Protein (His Tag)
| SKU # | PKSH033629 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | IMD, MGC, CTLA, CANDF, CDw, IL17RA, CANDF5, CD217, CDw217, IL-17RA, IL17R, IMD51, hIL-17R, CD127, CD217 antigen, CDW127, CTLA8, HIL 17R, hIL17R, I17RA, IL 17 receptor, IL 17 receptor A, IL 17RA, IL17, IL-17 R alpha, IL-17 receptor A, IL17A receptor, IL-17R, IL17R-A, IL17-RA, IL-17R-alpha, IL7RA, ILRA, Interleukin 17 receptor A, Interleukin-17 receptor A, MGC10262, CDw217, Interleukin-17 receptor A |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Leu33-Trp320 |
| Accession | Q96F46 |
| Calculated Molecular Weight | 34.5 kDa |
| Observed Molecular Weight | 50-80 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
CD38, also called ADP-ribosyl cyclase, is a Type II integral membrane protein with 301 amino acids in length that belongs to the ADP-ribosyl cyclase family.It synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. And also moonlights as a receptor in cells of the immune system. CD38 is expressed in B and T lymphocytes, osteoclasts, and in cardiac, pancreatic, liver and kidney cells. Through its production of cyclic ADP-ribose, CD38 modulates calcium-mediated signal transduction in many types of cells, including neutrophils and pancreatic beta cells.