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Recombinant Human IL1RL1/ST2 Protein (His Tag)
SKU: PKSH033314-50
Recombinant Human IL1RL1/ST2 Protein (His Tag)
| SKU # | PKSH033314 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | FIT, DER, IL1RL, IL-1 R, IL1RL1, DER4, FIT-1, IL33R, ST2, ST2L, ST2V, T1, IL-1 R4, DER-4, FIT 1, Growth stimulation expressed, Growth stimulation expressed gene 2, homolog of mouse growth stimulation-expressed, IL-1R4, ILRL1, Interleukin 1 receptor like 1, interleukin 1 receptor related protein, Interleukin-1 receptor-like 1, Protein ST2, T1 protein |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Lys19-Phe328 |
| Accession | Q01638-2 |
| Calculated Molecular Weight | 36.0 kDa |
| Observed Molecular Weight | 50-85 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Interleukin 1 receptor-like 1(IL1RL1) is a member of the interleukin-1 receptor family, Contains 3 Ig-like C2-type domains and 1 TIR domain. It is highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. IL1RL1 is a receptor for interleukin-33, its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. IL1RL1 may possibly be involved in helper T-cell function. Soluble IL1RL1 also acts as a negative regulator of Th2 cytokine production, it directly implicated in the progression of cardiac disease.