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Recombinant Human IL36G/IL1F9 Protein (Active)
SKU: PKSH032644-100
Recombinant Human IL36G/IL1F9 Protein (Active)
| SKU # | PKSH032644 |
| Expression Host | E.coli |
Description
| Synonyms | UNQ, PRO, IL1F, IL1H, IL-1-related protein, Interleukin-1 homolog, IL-1F, IL-1H, IL1RP, IL-1RP, IL36G, IL-1F9, IL-1H1, IL-1RP2, IL1E, IL1F9, IL1H1, IL1RP2, IL-1 epsilon, IL-1-related protein 2, Interleukin-1 homolog 1, Interleukin-36 gamma, UNQ2456, PRO5737 |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Ser18-Asp169 |
| Accession | Q9NZH8 |
| Calculated Molecular Weight | 18.0 kDa |
| Observed Molecular Weight | 19 kDa |
| Tag | C-His |
| Bio-activity | Measure by its ability to induce IL-8 secretion in A431 cells.The ED50 for this effect is <5 ng/mL. |
Properties
| Purity | > 98 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 0.1 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS,pH 8.0. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Interleukin-36 gamma (IL-36γ) is a member of the interleukin 1 cytokine family that includes three closely related genes, IL-36α, β, and γ, formerly known as IL-1F6, F8, and F9 respectively. IL-36α has been detected in both neuronal and synovial tissue, whereas IL-36β and IL-36γ are expressed in both cutaneous and mucosal epithelial cells, including the respiratory tract. IL-36β and IL-36γ stimulate proliferation, maturation and/or cytokine expression by innate immune cells (such as keratinocytes and dendritic cells), and adaptive immune cells (neutrophils and T-cells) in both humans and mice. The activity of IL-36α is mediated by interleukin 1 receptor-like 2 (IL1RL2/IL1R-rp2), and is specifically inhibited by interleukin 1 family, member 5 (IL1F5/IL-1 delta). IL-36γ plays an important role in communicating the cell death to surrounding cells.