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Recombinant Human IL7RA/CD127 Protein (His Tag)(Active)– MSE Supplies LLC

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Recombinant Human IL7RA/CD127 Protein (His Tag)(Active)

SKU: PKSH031327-100

  • $ 84695
  • Save $ 9400



Recombinant Human IL7RA/CD127 Protein (His Tag)(Active)

 

SKU # PKSH031327
Expression Host HEK293 Cells

 

 

Description

Synonyms CDW, IL7R, CD127, CDW127, IL-7R-alpha, IL7RA, ILRA, IL-7R, IL-7RA, IL-7Rα, Interleukin-7 receptor subunit alpha,  IL-7R&, alpha, CD 127, CD127 antigen, IL 7R, IL 7R alpha, IL-7 receptor subunit alpha, IL-7R subunit alpha, IL7Ralpha, Interleukin 7 receptor, Interleukin 7 receptor alpha chain, Interleukin 7 receptor isoform H5 6
Species Human
Expression Host HEK293 Cells
Sequence Met 1-Gly 236
Accession NP_002176.2
Calculated Molecular Weight 26.3 kDa
Observed Molecular Weight 45-50 kDa
Tag C-His
Bio-activity Measured by its ability to bind biotinylated mouse TSLP-his in functional ELISA.
  

 

Properties

Purity > 92 % as determined by reducing SDS-PAGE.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from sterile PBS, pH 7.4
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution Please refer to the printed manual for detailed information.


Background

Interleukin 7 Receptor alpha (IL-7RA), also known as CD127, is a 75 kDa hematopoietin receptor superfamily member that plays an important role in lymphocyte differentiation, proliferation, and survival. IL-7RA signaling is essential for T-cell development and regulation of naive and memory T-cell homeostasis. Studies from both pathogenic and controlled HIV infection indicate that the containment of immune activation and preservation of CD127 expression are critical to the stability of CD4(+) T cells in infection. A better understanding of the factors regulating CD127 expression in HIV disease, particularly on T(CM) cells, might unveil new approaches exploiting the IL-7/IL-7R receptor pathway to restore T cell homeostasis and promote immune reconstitution in HIV infection. Factors relevant to HIV infection that could potentially decrease CD127 expression on human CD8(+) T cells. CD127 down-regulation may be an important contributor to HIV-associated T-cell dysfunction. In addition to IL-7, IL-7RA also associates with TSLPR to form the functional receptor for thymic stromal lymphopoietin (TSLP) which indirectly regulates T cell development by modulating dendritic cell activation. Mutations in the human IL-7RA gene cause a type of severe combined immunodeficiency in which the major deficiencies are in T cell development, whereas B and NK cells are relatively normal in number. Soluble CD127 (sCD127) appears to play an important role in the immunopathogenesis of several chronic infections, multiple sclerosis, and various cancers.