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Recombinant Human ILT6/LILRA3 Protein (Fc Tag)
SKU: PKSH030602-100
Recombinant Human ILT6/LILRA3 Protein (Fc Tag)
| SKU # | PKSH030602 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | CD85 antigen-like family member E, CD85e, HM31, HM43, ILT-6, ILT6, Immunoglobulin-like transcript 6, LIR-4, LIR-4 and Monocyte inhibitory receptor HM43/HM31, LIR4, Leukocyte immunoglobulin-like receptor 4, Leukocyte immunoglobulin-like receptor subfamily A member 3 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Met 1-Glu439 |
| Accession | AAH28208.1 |
| Calculated Molecular Weight | 72.0 kDa |
| Observed Molecular Weight | 102 kDa |
| Tag | C-hFc |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 80 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4 Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
ILT6, also known as LILRA3, belongs to the ILT family. In human, the ILT gene family includes up to 11 members. The extracellular portion of all members includes at least two and usually four immuno-globulin domains. ILT-2 through 5 are all inhibitory members having variable numbers of cytoplasmic ITIM domains. ILT6 lacks a transmembrane domain. The function of ILT6 is currently unknown. however it is highly homologous to other LILR genes, and can bind human leukocyte antigen (HLA) class I. Therefore, if secreted, the ILT6 might impair interactions of membrane-bound LILRs (such as LILRB1, an inhibitory receptor expressed on effector and memory CD8 T cells) with their HLA ligands, thus modulating immune reactions and influencing susceptibility to disease.