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Recombinant Human Interleukin-13/IL-13 Protein (His Tag)(Active)
SKU: PKSH032617-50
Recombinant Human Interleukin-13/IL-13 Protein (His Tag)(Active)
| SKU # | PKSH032617 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | BHR, IL13, IL-13, P600, ALRH, BHR1, NC30, Interleukin-13 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Gly35-Asn146 |
| Accession | AAH96139 |
| Calculated Molecular Weight | 13.4 kDa |
| Observed Molecular Weight | 13-30 kDa |
| Tag | C-His |
| Bio-activity | Measured in a cell proliferation assay using TF‑1 human erythroleukemic cells. The ED50 for this effect is 1.5-4.5 ng/ml. |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 0.01 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Interleukin-13 is also known as IL-13. It is a protein that in humans is encoded by the IL13 gene. Interleukin-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells.It is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils.