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Recombinant Human Interleukin-17A/IL-17A Protein (Human Cells, His Tag)(Active)
SKU: PKSH032621-50
Recombinant Human Interleukin-17A/IL-17A Protein (Human Cells, His Tag)(Active)
| SKU # | PKSH032621 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | Cytotoxic T-lymphocyte-associated antigen, IL17A, CTLA-8, CTLA8, IL-17, IL-17A, IL17, Interleukin-17A, Cytotoxic T-lymphocyte-associated antigen 8, CTLA 8, CTLA8, CTLA-8, CTLA8cytotoxic T-lymphocyte-associated serine esterase 8, Cytotoxic T-lymphocyte-associated antigen 8, IL17, IL-17, IL17A, IL-17A, IL-17Acytotoxic T-lymphocyte-associated protein 8, IL-17CTLA-8, Cytotoxic T lymphocyte associated antigen 8, Cytotoxic T lymphocyte associated protein 8, Cytotoxic T lymphocyte associated serine esterase 8, IL 17A, Interleukin 17 (cytotoxic T lymphocyte associated serine esterase 8), Interleukin 17A, Interleukin17, Interleukin17A, OTTHUMP00000016597, OTTMUSP00000046003 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Gly24-Ala155 |
| Accession | Q16552 |
| Calculated Molecular Weight | 15.9 kDa |
| Observed Molecular Weight | 15-22 kDa |
| Tag | C-His |
| Bio-activity | Measured by its ability to induce IL-6 secretion by NIH‑3T3 mouse embryonic fibroblast cells. The ED50 for this effect is 1-10 ng/ml. |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 0.01 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. As IL-17 shares properties with IL-1 and TNF-alpha; it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis; and produced by rheumatoid arthritis synovium. It increases IL-6 production; induces collagen degradation and decreases collagen synthesis by synovium and cartilage and proteoglycan synthesis in cartilage. IL-17 is also able to increase bone destruction and reduce its formation. Blocking of interleukin-17 with specific inhibitors provides a protective inhibition of cartilage and bone degradation.