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Recombinant Human Interleukin-17D/IL-17D Protein
SKU: PKSH033627-100
Recombinant Human Interleukin-17D/IL-17D Protein
| SKU # | PKSH033627 |
| Expression Host | E.coli |
Description
| Synonyms | UNQ, IL 27, IL-27, IL 17D, IL-17D, IL27, Interleukin 17D, Interleukin 27, Interleukin-17D, Interleukin-27, IL17D, UNQ3096, PRO21175 |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Ala18-Pro202 |
| Accession | Q8TAD2 |
| Calculated Molecular Weight | 21.0 kDa |
| Observed Molecular Weight | 17-34 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 98 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 0.1 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS,pH 8.0. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
The Interleukin-17 family proteins, comprising six members (IL-17, IL-17B through IL-17F),are secreted, structurally related proteins that share a conserved cysteine-knot fold near the C-terminus, but have considerable sequence divergence at the N-terminus. IL-17 family proteins are proinflammatory cytokines that induce local cytokine production and are involved in the regulation of immune functions. Among IL-17 family members, IL-17D is most closely related to IL-17B, sharing 27% aa sequence homology. IL-17D is expressed preferentially in skeletal muscle, heart, adipose tissue, lung, pancreas, and nervous system. Like other IL-17 family members, IL-17D modulates immune responses indirectly by stimulating the production of myeloid growth factors and chemokines including IL-6, IL-8, and GM-CSF. IL-17D has also been shown to suppress the proliferation of myeloid progenitors in colony formation assays.