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Recombinant Human Interleukin-17F/IL-17F Protein (Active)
SKU: PKSH032622-100
Recombinant Human Interleukin-17F/IL-17F Protein (Active)
| SKU # | PKSH032622 |
| Expression Host | E.coli |
Description
| Synonyms | Cytokine ML, Interleukin, CANDF, IL17F, CANDF6, IL-17F, ML-1, ML1, Cytokine ML-1, IL24, IL-24, Interleukin-17F, Interleukin-24 |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Arg31-Gln163 |
| Accession | Q96PD4 |
| Calculated Molecular Weight | 15.8 kDa |
| Observed Molecular Weight | 18 kDa |
| Tag | C-His |
| Bio-activity | Measure by its ability to induce IL-6 secretion in 3T3 cells. The ED50 for this effect is <20 ng/mL. |
Properties
| Purity | > 98 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 0.1 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile 20 mM sodium acetate, pH 4.0. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. Today; IL-17 represents a family of structurally related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family; IL-17A through IL-17F; are secreted as homodimers. IL-17F also regulates cartilage matrix turnover and inhibits angiogenesis.