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Recombinant Human JAM-A/F11R Protein (His Tag)
SKU: PKSH033607-50
Recombinant Human JAM-A/F11R Protein (His Tag)
| SKU # | PKSH033607 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | CD321, F11R, JAM-1, JAM-A, JAM1, JAMA, JCAM, Junctional Adhesion Molecule 1, Junctional Adhesion Molecule A, KAT, PAM-1, Platelet Adhesion Molecule 1, Platelet F11 Receptor |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Ser28-Val238 |
| Accession | Q9Y624 |
| Calculated Molecular Weight | 23.9 kDa |
| Observed Molecular Weight | 28-31 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 100mM Glycine, pH 7.5. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Junctional Adhesion Molecule A (JAM-A) is a single-pass type I membrane protein that belongs to the immunoglobulin superfamily. JAM-A contains 2 Ig-like V-type (immunoglobulin-like) domains and Interacts with the ninth PDZ domain. JAM-A is localized to the tight junctions of both epithelial and endothelial cells. JAM-A seems to be involved in epithelial tight junction formation. JAM-A appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM-A, thereby preventing tight junction assembly. JAM-A plays a role in regulating monocyte transmigration involved in regulating integrity of the epithelial barrier. In the case of orthoreovirus infection, JAM-A serves as receptor for the virus.