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Recombinant Human Kallikrein 11/KLK11 Protein (His Tag)
SKU: PKSH033404-50
Recombinant Human Kallikrein 11/KLK11 Protein (His Tag)
| SKU # | PKSH033404 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | Hippostasin, KLK11, Kallikrein-11, PRSS20, Serine Protease 20, TLSP, Trypsin-Like Protease, hK11 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Glu19-Asn250 |
| Accession | AAH22068 |
| Calculated Molecular Weight | 26.3 kDa |
| Observed Molecular Weight | 38 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 2mM CaCl2, pH 8.0. |
| Reconstitution | Not Applicable |
Background
Human Kallikrein 11 (KLK11) is a member of tissue kallikrein family which are extracellular serine proteases consisting of 15 members. Two isoforms of KLK11 are differentially expressed. Isoform 1 is predominantly expressed in brain and isoform 2 is preferentially expressed in prostate. Isoform 1 consists of a signal peptide;a short pro peptide and the mature chain.Isoform 2 contains an extra 32 amino acid N terminal to full-length isoform 1.KLK11 is a novel marker for ovarian and prostate cancer carcinomas. KLK11 can be activated by thermolysin and is active against a thioester substrate.