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Recombinant Human Kallikrein 13/KLK13 Protein (His Tag)(Active)
SKU: PKSH031770-50
Recombinant Human Kallikrein 13/KLK13 Protein (His Tag)(Active)
| SKU # | PKSH031770 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | KLK-L4, KLK13, KLKL4, Kallikrein-13, Kallikrein-Like Protein 4 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Met 1-Ile 262 |
| Accession | NP_056411.1 |
| Calculated Molecular Weight | 28.4 kDa |
| Tag | C-His |
| Bio-activity | Measured by its ability to cleave the fluorogenic peptide substrate Boc-VPR-AMC (R&D Systems, Catalog # ES011). The specific activity is > 200 pmoles/min/μg. (Activation description: The proenzyme needs to be activated by Lysyl-Endopeptidase for an activated form) |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4 Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Tissue kallikrein 13 (hK13); also known as KLK-L4 (kallikrein-like gene 4); is a member of the human tissue kallikrein family of serine proteases having diverse physiological functions in many tissues. The KLK13 gene resides on chromosome 19q13.3-4 along with other 14 members in a gene cluster and shares a high degree of homology. KLK13 is a trypsin-like; secreted serine protease expressed specifically in the testicular tissue including prostate; salivary gland; breast; and testis. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and may play a role in metastasis. KLK13 may be involved in the pathogenesis and/or progression of breast and ovary cancers; and is regarded as a novel cancer biomarker. In addition; KLK13 interacts and forms complexes with several serum protease inhibitors; such as alpha2-macroglobulin; and its expression is regulated by steroid hormones.