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Recombinant Human Kallikrein 2/KLK2 Protein (His Tag)
SKU: PKSH032666-50
Recombinant Human Kallikrein 2/KLK2 Protein (His Tag)
| SKU # | PKSH032666 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | Glandular Kallikrein-1, KLK2, Kallikrein-2, Tissue Kallikrein-2, hGK-1 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Pro19-Pro261 |
| Accession | P20151 |
| Calculated Molecular Weight | 27.9 kDa |
| Observed Molecular Weight | 10-12&16-19&28-33 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 0.01 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Acetate, 250mM Trehalose, 0.02% Tween 80, pH5.0. |
| Reconstitution | Not Applicable |
Background
Kallikrein-2 (KLK2) is a secreted serine protease that belongs to the peptidase S1 family of Kallikrein subfamily. KLK2 contains 1 peptidase S1 domain. It is highly expressed in the human prostate gland. KLK2 can cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin, but Preferential cleavages of Arg-|-Xaa bonds in small molecule substrates. It also highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa. KLK2 is inhibited by serpins such as protein C inhibitor, antichymotrypsin, and plasminogen. KLK2 is considered to be a biomarker for prostate cancer.