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Recombinant Human LAMTOR3/MP1 Protein (His Tag)
SKU: PKSH032742-50
Recombinant Human LAMTOR3/MP1 Protein (His Tag)
| SKU # | PKSH032742 |
| Expression Host | E.coli |
Description
| Synonyms | LAMTOR3, Late Endosomal/Lysosomal Adaptor and MAPK and MTOR Activator 3, MAP2K1IP, MEK-Binding Partner 1, Mitogen-Activated Protein Kinase Kinase 1-Interacting Protein 1, Mitogen-Activated Protein Kinase Scaffold Protein 1, Mp1, Ragulator Complex Protein LAMTOR3 |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met 1-Val124 |
| Accession | Q9UHA4 |
| Calculated Molecular Weight | 15.8 kDa |
| Observed Molecular Weight | 15 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 100mM NaCl, 5mM DTT, 30% Glycerol, pH 8.0. |
| Reconstitution | Not Applicable |
Background
Mitogen-Activated Protein Kinase Scaffold Protein 1 (MAPKSP1) was identified as an interacting protein that belongs to the LAMTOR3 family. MAPKSP1 restricted to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. MAPKSP1 interacts with MAP2K1/MEK1 and MAPK2 and enhances the activation of MAPK2, and thus is thought to function as an adaptor to enhance the efficiency of the MAP kinase cascade.