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Recombinant Human LMIR2/CD300C Protein (Fc Tag)
SKU: PKSH032702-50
Recombinant Human LMIR2/CD300C Protein (Fc Tag)
| SKU # | PKSH032702 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | CD300 Antigen-Like Family Member C, CD300C, CD300c, CLM-6, CMRF-35, CMRF35, CMRF35-A1, CMRF35-Like Molecule 6, CMRF35A, CMRF35A1, IGSF16, IgSF16, Immunoglobulin Superfamily Member 16 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Gly21-Arg183 |
| Accession | Q08708 |
| Calculated Molecular Weight | 44.9 kDa |
| Observed Molecular Weight | 60-90 kDa |
| Tag | C-Fc |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 90 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
CD300C is a single-pass type I membrane protein which belongs to the immunoregulatory signaling (IRS) family. CD300C contains one Ig-like V-type domain and is present on the surface of natural killer cells; granulocytes; most myeloid cells; dendritic cells; and a subpopulation of T and B lymphocytes. The CD300C (CMRF-35A) and CD300A (CMRF-35H) molecules are homologous leukocyte surface proteins. CD300a and CD300C play an important role in the cross-regulation of TNF-alpha and IFN-alpha secretion from pDCs. CD300A and CD300C are indistinguishable on the surface of NK cells. The ligand for CD300C is presently unknown.