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Recombinant Human MGAT2/GlcNAc-TII Protein (His Tag)
SKU: PKSH032737-50
Recombinant Human MGAT2/GlcNAc-TII Protein (His Tag)
| SKU # | PKSH032737 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | 2-N-acetylglucosaminyltransferase II, 6-Mannosyl-Glycoprotein 2-Beta-N-Acetylglucosaminyltransferase, Alpha-1, Beta-1, GlcNAc-T II, MGAT2, Mannoside Acetylglucosaminyltransferase 2, N-Glycosyl-Oligosaccharide-Glycoprotein N-Acetylglucosaminyltransferase II, NT-II |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Arg30-Gln447 |
| Accession | Q10469 |
| Calculated Molecular Weight | 49.3 kDa |
| Observed Molecular Weight | 50 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0. |
| Reconstitution | Not Applicable |
Background
Mannoside Acetylglucosaminyltransferase 2 (MGAT2) is a single-pass type II membrane protein that contains the typical glycosyltransferase domains: a short N-terminal cytoplasmic domain, a hydrophobic non-cleavable signal-anchor domain and a C-terminal catalytic domain. MGAT2 catalyzes an essential step in the conversion of oligo-mannose to complex N-glycans. Defects in MGAT2 are the cause of congenital disorder of glycosylation type 2A.