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Recombinant Human/Mouse USP46 Protein (SUMO Tag)– MSE Supplies LLC

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Recombinant Human/Mouse USP46 Protein (SUMO Tag)

SKU: PKSH030765-100

  • $ 76995
  • Save $ 8600



Recombinant Human/Mouse USP46 Protein (SUMO Tag)

 

SKU # PKSH030765
Expression Host Baculovirus-Insect Cells

 

Description

Synonyms USP46
Species Human
Expression Host Baculovirus-Insect Cells
Sequence Met 1-Glu366
Accession NP_808229.1
Calculated Molecular Weight 55.2 kDa
Observed Molecular Weight 64 kDa
Tag N-SUMO
Bio-activity Not validated for activity
  

 

Properties

Purity > 90 % as determined by reducing SDS-PAGE.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 7.4, 10% glycerol
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution Please refer to the printed manual for detailed information.


Background

USP46 belongs to the peptidase C19 family; USP12/USP46 subfamily. Deubiquitinating enzymes (DUBs) are a large group of proteases which are also commonly referred to as deubiquitinating peptidases; deubiquitinating isopeptidases; deubiquitinases; ubiquitin proteases; ubiquitin hydrolyases; ubiquitin isopeptidases; or Dubs. They regulate ubiquitin-dependent metabolic pathways by cleaving ubiquitin-protein bonds. They also may act as negative and positive regulators of the ubiquitin system. Besides ubiquitin recycling; they are also involved in processing of ubiquitin precursors; in proofreading of protein ubiquitination and in disassembly of inhibitory ubiquitin chains. USP46 is a deubiquitinating enzyme that plays a role in behavior; possibly by regulating GABA action. It may act by mediating the deubiquitination of GAD1/GAD67. USP46 has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity and it is not involved in deubiquitination of monoubiquitinated FANCD2.