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Recombinant Human MPZL1 Protein (His Tag)
SKU: PKSH032771-50
Recombinant Human MPZL1 Protein (His Tag)
| SKU # | PKSH032771 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | FLJ96614, Homo sapiens myelin protein zero-like 1 (MPZL1), Mrna, Myelin protein zero-like 1, cDNA, cDNA FLJ78597, highly similar to Homo sapiens myelin protein zero-like 1 (MPZL1), isoform CRA_b, mRNA, transcript variant 1 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Ser36-Val162 |
| Accession | O95297 |
| Calculated Molecular Weight | 15.2 kDa |
| Observed Molecular Weight | 20-28 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Myelin protein zero-like protein 1(MPZL1) is encoded by the MPZL1 gene, which is a single-pass type I membrane protein. It is widely expressed with highest levels in heart, placenta, kidney and pancreas. As cell surface receptor, it involved in signal transduction processes. MPZL1 recruits PTPN11/SHP-2 to the cell membrane and subsequently activate/phosphorylate Src kinase at Tyr426, promoting phosphorylation of cortactin and migration of HCC cells. MPZL1also is a major receptor for concanavalin-A (ConA) and involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases.