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Recombinant Human MTHFS Protein (His Tag)– MSE Supplies LLC

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Recombinant Human MTHFS Protein (His Tag)

SKU: PKSH032029-50

  • $ 53395
  • Save $ 6000



Recombinant Human MTHFS Protein (His Tag)

 

SKU # PKSH032029
Expression Host E.coli

 

 

Description

Synonyms 5,10-methenyl-tetrahydrofolate synthetase, 5-formyltetrahydrofolate cyclo-ligase, MTHFS, Methenyl-THF synthetase
Species Human
Expression Host E.coli
Sequence Met 1-Ala203
Accession P49914
Calculated Molecular Weight 24.3 kDa
Observed Molecular Weight 28 kDa
Tag C-His
Bio-activity Not validated for activity
  

 

Properties

Purity > 95 % as determined by reducing SDS-PAGE.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 200mM Nacl, 1mM DTT, 50% Glycerol, pH 8.0.
Reconstitution Not Applicable



Background

5-formyltetrahydrofolate cyclo-ligase (MTHFS) belongs to the 5-formyltetrahydrofolate cyclo-ligase family. It is an enzyme that catalyzes the conversion of 5-formyltetrahydrofolate to 5,10-methenyltetrahydrofolate, contributes to tetrahydrofolate metabolism. MTHFS helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. An increased activity of the encoded protein can result in an increased folate turnover rate and folate depletion.