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Recombinant Human NANS/SAS Protein (His Tag)
SKU: PKSH032780-50
Recombinant Human NANS/SAS Protein (His Tag)
| SKU # | PKSH032780 |
| Expression Host | E.coli |
Description
| Synonyms | N-Acetylneuraminate Synthase, N-Acetylneuraminate-9-Phosphate Synthase, N-Acetylneuraminic Acid Phosphate Synthase, N-Acetylneuraminic Acid Synthase, NANS, SAS, Sialic Acid Synthase |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met 1-Ser359 |
| Accession | AAH19315.1 |
| Calculated Molecular Weight | 42.4 kDa |
| Observed Molecular Weight | 42 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 80 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 100mM NaCl, pH 8.0. |
| Reconstitution | Not Applicable |
Background
Sialic Acid Synthase (NANS) is an enzyme that contains one AFP-like domain. NANS is ubiquitous and plays a role in the biosynthetic pathways of sialic acids. NANS produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN). It also can use N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively.