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Recombinant Human NDRG1 Protein (His Tag)
SKU: PKSH032818-50
Recombinant Human NDRG1 Protein (His Tag)
| SKU # | PKSH032818 |
| Expression Host | E.coli |
Description
| Synonyms | CAP43, DRG-1, DRG1, Differentiation-Related Gene 1 Protein, N-myc Downstream-Regulated Gene 1 Protein, NDRG1, Nickel-Specific Induction Protein Cap43, Protein NDRG1, RTP, Reducing Agents and Tunicamycin-Responsive Protein, Rit42 |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met 1-Cys394 |
| Accession | Q92597 |
| Calculated Molecular Weight | 45.0 kDa |
| Observed Molecular Weight | 52 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 90 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Protein NDRG1 is a member of the N-Myc Downregulated Gene family, which is part of the α/β Hydrolase superfamily. Protein NDRG1 is a cytoplasmic protein that is involved in stress responses, hormone responses, cell growth and differentiation. Protein NDRG1 is necessary for p53-mediated caspase activation and apoptosis. Protein NDRG1 mutuations are reported to be the cause for hereditary motor and sensory neuropathy-Lom. Decreased NDRG1 expression in glioma is linked to tumor progression; overexpression of NDRG1 is connected to malignant status of esophageal cancer.