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Recombinant Human Neurotrophin 3/NTF3 protein (His tag)
SKU: PDEH100226-100
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Recombinant Human Neurotrophin 3/NTF3 protein (His tag)
| SKU # | PDEH100226 |
| Expression Host | E. coli |
Description
| Synonyms | Neurotrophin-3;NT-3;HDNF;Nerve Growth Factor 2;NGF-2;Neurotrophic Factor;NTF3 |
| Species | Human |
| Expression_host | E.coli |
| Sequence | Tyr 139-Thr 257 |
| Accession | P20783-1 |
| Mol_Mass | 13.0 kDa |
| AP_Mol_Mass | 16 kDa |
| Tag | N-His |
| Bio_Activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin level | Please contact us for more information. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis |
Background
Neurotrophin-3 (NT-3) is a member of the NGF family of neurotrophic factors and is structurally related to β-NGF, BDNF and NT-4. The NT3 cDNA encodes a 257 amino acid residue precursor protein with a signal peptide and a proprotein that are cleaved to yield the 119 amino acid residue mature NT3.The amino acid sequences of mature human, murine and rat NT-3 are identical. NT-3 selectively promotes the differentiation and survival of specific neuronal subpopulations in both the central as well as the peripheral nervous systems.