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Recombinant Human NHP2/NOLA2 Protein (His Tag)
SKU: PKSH032829-50
Recombinant Human NHP2/NOLA2 Protein (His Tag)
| SKU # | PKSH032829 |
| Expression Host | E.coli |
Description
| Synonyms | H/ACA ribonucleoprotein complex subunit 2, NHP2, NHP2P. , NOLA2, Nucleolar protein family A member 2, snoRNP protein NHP2 |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met 1-Leu153 |
| Accession | Q9NX24 |
| Calculated Molecular Weight | 19.3 kDa |
| Observed Molecular Weight | 22 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 100mM NaCl, 1mM DTT, pH 8.0. |
| Reconstitution | Not Applicable |
Background
NHP2 belongs to the H/ACA snoRNPs gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been organized into 2 families: C/D and H/ACA. NHP2 forms a small ribonucleoprotein particle with GAR1 (NOLA1). NHP2 is involved in a variety of aspects of rRNA processing and modification. NHP2 localizes to the dense fibrillar component of the nucleolus and in nuclear Cajal bodies. NHP2 may also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.