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Recombinant Human NKG2A & CD94 Heterodimer Protein (His & Flag Tag)
SKU: PKSH032812-50
Recombinant Human NKG2A & CD94 Heterodimer Protein (His & Flag Tag)
| SKU # | PKSH032812 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | CD159A&KLRD1 Heterodimer , KLRC1&CD94 Heterodimer, NKG2A&CD94 Heterodimer |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Arg100-Leu233 & Ser34-Ile179 |
| Accession | P26715&Q13241 |
| Calculated Molecular Weight | 34.4 kDa |
| Observed Molecular Weight | 25-40 kDa |
| Tag | N-His & N-Flag |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
NKG2-A/NKG2-B Type II Integral Membrane Protein contains 1 C-type lectin domain and belongs to the killer cell lectin-like receptor family. The killer cell lectin-like receptor family is a group of transmembrane proteins preferentially expressed in NK cells. Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. CD94 (Cluster of Differentiation 94), also known as killer cell lectin-like receptor subfamily D member 1 (KLRD1), is expressed on the surface of natural killer cells in the innate immune system. CD94 Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. CD94 Can form disulfide-bonded heterodimer with NKG2 family members. The CD94/NKG2 complex, on the surface of natural killer cells interacts with Human Leukocyte Antigen (HLA)-E on target cells.