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Recombinant Human NME1/NDKA Protein (His Tag)
SKU: PKSH032830-50
Recombinant Human NME1/NDKA Protein (His Tag)
| SKU # | PKSH032830 |
| Expression Host | E.coli |
Description
| Synonyms | AWD, GAAD, Granzyme A-Activated DNase, Metastasis Inhibition Factor nm23, NB, NBS, NDK A, NDKA, NDP Kinase A, NDPK-A, NDPKA, NM23, NM23-H1, NME1, Nucleoside Diphosphate Kinase A, Tumor Metastatic Process-Associated Protein, nm23-H1 |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met 1-Glu152 |
| Accession | P15531 |
| Calculated Molecular Weight | 19.3 kDa |
| Observed Molecular Weight | 21 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 1mM DTT, 10% Glycerol, pH 7.5. |
| Reconstitution | Not Applicable |
Background
Nucleoside-Diphosphate Kinases (NDKs) are enzymes that catalyze the exchange of phosphate groups between different nucleoside diphosphates. NDKs Possesse nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3-5 exonuclease activities. NDKs involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression and required for neural development including neural patterning and cell fate determination. Prokaryotic NDK forms a functional homotetramer.There are two isoforms of NDK in humans: NDK-A and NDK-B. Both have very similar structure, and can combine in any proportion to form functional NDK hexamers.