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Recombinant Human OX40/TNFRSF4 Protein (His Tag)(Active)– MSE Supplies LLC

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Recombinant Human OX40/TNFRSF4 Protein (His Tag)(Active)

SKU: PKSH033416-50

  • $ 30595
  • Save $ 3400



Recombinant Human OX40/TNFRSF4 Protein (His Tag)(Active)

 

SKU # PKSH033416
Expression Host HEK293 Cells

 

 

Description

Synonyms ACT35, CD134, IMD16, OX40, TNFRSF4, TXGP1L, Tumor necrosis factor receptor superfamily member 4, Txgp1
Species Human
Expression Host HEK293 Cells
Sequence Leu29-Ala216
Accession P43489
Calculated Molecular Weight 21.0 kDa
Observed Molecular Weight 38-45 kDa
Tag C-His
Bio-activity Immobilized Mouse OX40L-His at 10μg/ml (100 μl/well) can bind Human OX40-6His.*: Biotinylated by NHS-biotin prior to testing The ED50 of Recombinant Human OX40-6His(Cat#CK60) is 1.44 ug/ml.
  

 

Properties

Purity > 95 % as determined by reducing SDS-PAGE.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution Please refer to the printed manual for detailed information.



Background

OX40, also termed CD134 and TNFRSF4, is a T cell co-stimulatory molecule of the TNF receptor superfamily which plays a key role in the survival and homeostasis of effector and memory T cells. OX40 is expressed on CD4+ and CD8+ T cells upon engagement of the TCR by antigen presenting cells along with co-stimulation by CD40-CD40 Ligand and CD28-B7. The interaction between OX40 and OX40 ligand (OX40L) will occur when activated T cells bind to professional antigen-presenting cells (APCs). The T-cell functions, including cytokine production, expansion, and survival, are then enhanced by the OX40 costimulatory signals. OX40 signals are critical for controlling the function and differentiation of Foxp3+ regulatory T cells. OX40-OX40L interaction regulates T-cell tolerance, peripheral T-cell homeostasis, and T-cell-mediated inflammatory diseases.