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Recombinant Human P-glycoprotein1/ABCB1 protein (His tag)
SKU: PDEH100361-100
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Recombinant Human P-glycoprotein1/ABCB1 protein (His tag)
| SKU # | PDEH100361 |
| Expression Host | E. coli |
Description
| Synonyms | ATP-dependent translocase ABCB1;ABCB1;ATP-binding cassette sub-family B member 1;P-glycoprotein 1;Phospholipid transporter ABCB1;CD243; |
| Species | Human |
| Expression_host | E.coli |
| Sequence | Leu 392-Met 628 |
| Accession | P08183 |
| Mol_Mass | 26.0 kDa |
| AP_Mol_Mass | 32 kDa |
| Tag | N-His |
| Bio_Activity | Not validated for activity |
Propertie
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin level | Please contact us for more information. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis |
Background
Translocates drugs and phospholipids across the membrane (PubMed:8898203, PubMed:2897240, PubMed:9038218, PubMed:35970996). Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins (PubMed:8898203). Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells (PubMed:2897240, PubMed:9038218, PubMed:35970996).