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Recombinant Human P21 protein (His tag)
SKU: PDEH100242-100
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Recombinant Human P21 protein (His tag)
| SKU # | PDEH100242 |
| Expression Host | E. coli |
Description
| Synonyms | CAP20;CDK-interacting protein 1;CDKI;CDKN1;CDN1A;CIP1;CDKN1A;Cyclin Dependent Kinase Inhibitor 1A;DNA Synthesis Inhibitor;MDA-6;MDA6;Melanoma differentiation-associated protein 6;P21cip1;P21waf;PIC1;SDI1;SLC12A9;WAF1 |
| Species | Human |
| Expression_host | E.coli |
| Sequence | Gly 40-Pro 164 |
| Accession | P38936 |
| Mol_Mass | 13.6 kDa |
| AP_Mol_Mass | 18 kDa |
| Tag | N-His |
| Bio_Activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin level | Please contact us for more information. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis |
Background
May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex.