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Recombinant Human PADI4 Protein (His Tag)
SKU: PKSH032973-50
Recombinant Human PADI4 Protein (His Tag)
| SKU # | PKSH032973 |
| Expression Host | E.coli |
Description
| Synonyms | HL-60 PAD, PADI4, PADI5, PDI5, Peptidylarginine Deiminase IV, Protein-Arginine Deiminase Type-4, Protein-arginine Deiminase type IV |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met 1-Pro663 |
| Accession | AAH25718.1 |
| Calculated Molecular Weight | 76.2 kDa |
| Observed Molecular Weight | 78 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 50mM Tris-HCl, 500mM NaCl, pH 7.5. |
| Reconstitution | Not Applicable |
Background
Protein-Arginine Deiminase Type-4 (PADI4) belongs to the Protein Arginine Deiminase family. PADI4 is expressed in eosinophils and neutrophils, but it is not expressed in peripheral monocytes or lymphocytes. PADI4 catalyzes the citrullination/deimination of arginine residues of proteins. In addition, PADI4 may play an important role in tumourigenesis. Genetic variations in PADI4 are a cause of susceptibility to rheumatoid arthritis (RA), which is a systemic inflammatory disease with autoimmune features and a complex genetic component.