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Recombinant Human PD-L2/CD273 Protein (His Tag)
SKU: PDMH100020-100
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Recombinant Human PD-L2/CD273 Protein (His Tag)
| SKU # | PDMH100020 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | B7-DC, B7DC, Butyrophilin B7-DC, CD273, PD-1 Ligand 2, PD-L2, PDCD1 Ligand 2, PDCD1L2, PDCD1LG2, PDL2, Programmed Cell Death 1 Ligand 2, Programmed Death Ligand 2 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Leu20-Pro219 |
| Accession | Q9BQ51 |
| Calculated Molecular Weight | 23.6 kDa |
| Observed Molecular Weight | 34-50 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis |
Background
Programmed Cell Death 1 Ligand 2 (PDCD1LG2) is a member of the BTN/MOG family. PDCD1LG2 contains one Ig-like C2-type domain and one Ig-like V-type domain. PDCD1LG2 is highly expressed in the heart; placenta; pancreas; lung and liver; it is weakly expressed in the spleen; lymph nodes; and thymus. PDCD1LG2 is involved in the costimulatory signal; essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. PDCD1LG2 interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.