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Recombinant Human Peroxiredoxin-3/PRDX3 Protein
SKU: PKSH032882-50
Recombinant Human Peroxiredoxin-3/PRDX3 Protein
| SKU # | PKSH032882 |
| Expression Host | E.coli |
Description
| Synonyms | AOP-1, AOP1, Antioxidant Protein 1, HBC189, PRDX3, Peroxiredoxin III, Peroxiredoxin-3, Protein MER5 homolog, Prx-III, Thioredoxin-Dependent Peroxide Reductase Mitochondrial |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Pro63-Gln256 |
| Accession | P30048 |
| Calculated Molecular Weight | 21.6 kDa |
| Observed Molecular Weight | 25 kDa |
| Tag | None |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, pH 8.0. |
| Reconstitution | Not Applicable |
Background
Thioredoxin-Dependent Peroxide Reductase Mitochondrial (PRDX3) is an enzyme that belongs to the AhpC/TSA family. Human and mouse PRDX3 genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Human PRDX3 protein has an antioxidant function and is localized in the mitochondrion. PRDX3 is involved in redox regulation of the cell. PRDX3 protects radical-sensitive enzymes from oxidative damage by a radical-generating system. It acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol.