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Recombinant Human PPM1G/PP2C-gamma Protein (aa 317-546, His Tag)
SKU: PKSH031182-100
Recombinant Human PPM1G/PP2C-gamma Protein (aa 317-546, His Tag)
| SKU # | PKSH031182 |
| Expression Host | E.coli |
Description
| Synonyms | PP2C-Gamma, PP2CG, PP2CGAMMA, PPM1G, Protein Phosphatase 1C, Protein Phosphatase 1G, Protein Phosphatase 2C Isoform Gamma, Protein Phosphatase Magnesium-Dependent 1 Gamma |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met 317-Asp 546 |
| Accession | O15355 |
| Calculated Molecular Weight | 26.6 kDa |
| Observed Molecular Weight | 30 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | Please contact us for more information. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile 50mM Tris, 1mM DTT, 20% glycerol, pH 7.5 Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Protein phosphatase 1G; also known as Protein phosphatase 1C; Protein phosphatase 2C isoform gamma; Protein phosphatase magnesium-dependent 1 gamma; PP2C-gamma; PPM1G and PPM1C; is a cytoplasm protein which belongs to thePP2C family. PPM1G / PP2C-gamma is widely expressed. It is most abundant in testis; skeletal muscle; and heart. Alternatively spliced transcript variants encoding the same protein have been described. PP2C family members are known to be negative regulators of cell stress response pathways. PPM1G / PP2C-gamma is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors; which is important for the formation of functional spliceosome. PPM1G / PP2C-gamma also plays a role in regulating cell cycle progression.