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Recombinant Human PPP1CC Protein (His Tag)
SKU: PKSH032969-50
Recombinant Human PPP1CC Protein (His Tag)
| SKU # | PKSH032969 |
| Expression Host | E.coli |
Description
| Synonyms | PP-1G, PPP1CC, Protein Phosphatase 1C Catalytic Subunit, Serine/Threonine-Protein Phosphatase PP1-Gamma Catalytic Subunit |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met 1-Lys323 |
| Accession | P36873 |
| Calculated Molecular Weight | 40.2 kDa |
| Observed Molecular Weight | 30-40 kDa |
| Tag | N-His & C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 85 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 1mM DTT, pH 8.0. |
| Reconstitution | Not Applicable |
Background
Serine/Threonine-Protein Phosphatase PP1-Υ Catalytic Subunit (PPP1CC) is a member of the PPP phosphatase family. It is essential for cell division, participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. PPP1CC colocalizes with SPZ1 in the nucleus, with URI1 at mitochondrion, Rapidly exchanges between the nucleolar, nucleoplasmic and cytoplasmic compartments. As a cofactor, PPP1CC binds one iron ion and one manganese ion per subunit.. In addition, PPP1CC may play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca2+/calmodulin dependent protein kinase II.