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Recombinant Human Receptor Tyrosine-Protein Kinase ErbB-3/HER3 (C-6His)
SKU: PKSH033900-50
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Recombinant Human Receptor Tyrosine-Protein Kinase ErbB-3/HER3 (C-6His)
| SKU # | PKSH033900 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | ERBB3, HER3, Proto-oncogene-like protein c-ErbB-3, Tyrosine kinase-type cell surface receptor HER3 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Ser20-Thr643 |
| Accession | P21860 |
| Calculated Molecular Weight | 69.5 kDa |
| Observed Molecular Weight | 85-100 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, 50% Glycerol, pH7.4. |
| Reconstitution | Not Applicable |
Background
Receptor tyrosine-protein kinase erbB-3 is an enzyme that in humans is encoded by the ERBB3 gene. This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. ERBB3 belongs to the protein kinase superfamily,tyr protein kinase family and EGF receptor subfamily.It contains 1 protein kinase domain and it is expressed in Epithelial tissues and brain. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity.