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Recombinant Human S100A8&S100A9 Heterodimer Protein (His Tag)
SKU: PKSH033381-50
Recombinant Human S100A8&S100A9 Heterodimer Protein (His Tag)
| SKU # | PKSH033381 |
| Expression Host | E.coli |
Description
| Synonyms | S100A8/S100A9 Heterodimer |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met 1-Glu93(S100A8)&Thr 2-Pro114(S100A9) |
| Accession | P05109&P06702 |
| Calculated Molecular Weight | 11.7&13.2 kDa |
| Observed Molecular Weight | 13&15 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM HEPES, 10% Glycerol, 150mM NaCl, 2.5mM EDTA, pH 7.4. |
| Reconstitution | Not Applicable |
Background
S100A8 is a member of the S100 family, EF-hand superfamily of Ca-binding proteins. It is produced by neutrophils and monocytes, and forms Ca2+-dependent heterodimer/heterotetramer complexes (termed calprotectin) with S100A9. Calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase.