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Recombinant Human SENP7 Protein (His Tag)
SKU: PKSH033027-50
Recombinant Human SENP7 Protein (His Tag)
| SKU # | PKSH033027 |
| Expression Host | E.coli |
Description
| Synonyms | KIAA1707, SENP7, SSP2, SUMO-1-Specific Protease 2, SUSP2, Sentrin-Specific Protease 7, Sentrin/SUMO-Specific Protease SENP7 |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met695-Ala864 |
| Accession | Q9BQF6 |
| Calculated Molecular Weight | 19.8 kDa |
| Observed Molecular Weight | 22 kDa |
| Tag | None |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM HEPES, 5% Glycerol, pH 7.4. |
| Reconstitution | Not Applicable |
Background
Sentrin-Specific Protease 7 (SENP7) acts as a SUMO-2/3-specific protease. SENP7 is likely to regulate the metabolism of poly-SUMO-2/3 rather than SUMO-1 conjugation in vivo. SENP7 has a restricted substrate specificity, and displaying paralogue-specific isopeptidase activity. The C-terminal catalytic domain of SENP7 depolymerized poly-SUMO-2 chains but does not have activity against poly-SUMO-1 chains. SENP7 also had isopeptidase activity against di-SUMO-2- and SUMO-2-modified RanGAP1 (Ran GTPase-activating protein 1) but had limited activity against SUMO-1-modified RanGAP1.