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Recombinant Human SerpinB3/SCCA1 Protein (E.coli, His Tag)
SKU: PKSH033038-50
Recombinant Human SerpinB3/SCCA1 Protein (E.coli, His Tag)
| SKU # | PKSH033038 |
| Expression Host | E.coli |
Description
| Synonyms | HsT1196, Protein T4-A, SCC, SCCA-1, SCCA1, Serpin B3, Squamous cell carcinoma antigen 1, T4-A, clade B (ovalbumin), member 3, serine (or cysteine) proteinase inhibitor, serpin peptidase inhibitor |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met 1-Pro390 |
| Accession | P29508 |
| Calculated Molecular Weight | 46.0 kDa |
| Observed Molecular Weight | 40-55 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Serpin B3, also known as squamous cell carcinoma antigen-1 (SCCA-1), is a member of the serpin superfamily of serine protease inhibitors. Serpin B3 belongs to the subgroup ovalbumin-related serpins which are involved in the regulation of apoptosis, inflammation, angiogenesis and embryogenesis. It may act as a papain-like cysteine protease inhibitor to modulate the host immune response against tumor cells. It also functions as an inhibitor of UV-induced apoptosis via suppression of the activity of c-Jun NH(2)-terminal kinase (JNK1).