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Recombinant Human SIRPB1/CD172b Protein (His Tag)
SKU: PKSH033523-50
Recombinant Human SIRPB1/CD172b Protein (His Tag)
| SKU # | PKSH033523 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | CD172 antigen-like family member B, CD172b, SIRP-beta-1, SIRPB1, Signal-regulatory protein beta-1 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Glu30-Glu362 |
| Accession | O00241 |
| Calculated Molecular Weight | 37.4 kDa |
| Observed Molecular Weight | 45-55 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Signal-regulatory protein beta-1 (SIRPB1, CD172b) is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK.