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Recombinant Human SOD2/Mn-SOD Protein (His Tag)
SKU: PKSH033072-50
Recombinant Human SOD2/Mn-SOD Protein (His Tag)
| SKU # | PKSH033072 |
| Expression Host | E.coli |
Description
| Synonyms | SOD2, Superoxide Dismutase [Mn] Mitochondrial |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Lys25-Lys222 |
| Accession | P04179 |
| Calculated Molecular Weight | 23.7 kDa |
| Observed Molecular Weight | 25 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 100mM NaCl, 50% Glycerol, pH 8.0. |
| Reconstitution | Not Applicable |
Background
Superoxide Dismutase (SOD2) is a number of the iron/manganese superoxide dismutase family. SOD2 is a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. The SOD2 protein transforms toxic superoxide and a byproduct of the mitochondrial electron transport chain into hydrogen peroxide and diatomic oxygen. Genetic variation in SOD2 is associated with microvascular complications of diabetes type 6 (MVCD6); idiopathic cardiomyopathy (IDC); sporadic motor neuron disease; and cancer. SOD2 destroys superoxide anion radicals which are usually produced within the cells and which are toxic to biological systems.