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Recombinant Human TIMP2/TIMP-2 Protein (His Tag)
SKU: PKSH033118-50
Recombinant Human TIMP2/TIMP-2 Protein (His Tag)
| SKU # | PKSH033118 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | CSC-21K, DDC8, Metalloproteinase Inhibitor 2, Tissue Inhibitor of Metalloproteinases 2 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Cys27-Pro220 |
| Accession | P16035 |
| Calculated Molecular Weight | 22.8 kDa |
| Observed Molecular Weight | 26 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Tissue inhibitors of metalloproteinases or TIMPs are a family of proteins that regulate the activation and proteolytic activity of the zinc enzymes known as matrix metalloproteinases (MMPs). There are four members of the family, TIMP-1, TIMP-2, TIMP-3, and TIMP-4. Tissue Inhibitor of Metalloproteinases 2 (TIMP-2) is a non N-glycosylated protein with a molecular mass of 22 kDa. It produced by a wide range of cell types, which inhibits MMPs non-covalently by the formation of binary complexes and irreversibly inactivates them by binding to their catalytic zinc cofactor. TIMP-2 also has erythroid-potentiating and cell growth promoting activities.