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Recombinant Human TPP1/CLN2 Protein (His Tag)– MSE Supplies LLC

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Recombinant Human TPP1/CLN2 Protein (His Tag)

SKU: PKSH033493-50

  • $ 53395
  • Save $ 6000



Recombinant Human TPP1/CLN2 Protein (His Tag)

 

SKU # PKSH033493
Expression Host HEK293 Cells

 

 

Description

Synonyms CLN2, Cell Growth-Inhibiting Gene 1 Protein, GIG1, LPIC, Lysosomal Pepstatin-Insensitive Protease, SCAR7, TPP-1, TPP1, Tripeptidyl Aminopeptidase, Tripeptidyl-Peptidase 1
Species Human
Expression Host HEK293 Cells
Sequence Ser20-Pro563
Accession AAH14863.1
Calculated Molecular Weight 60.4 kDa
Observed Molecular Weight 74 kDa
Tag C-His
Bio-activity Not validated for activity
  

 

Properties

Purity > 95 % as determined by reducing SDS-PAGE.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 1mM CaCl2, 10% Glycerol, pH 7.5.
Reconstitution Not Applicable



Background

Tripeptidyl-Peptidase 1 (TPP1) belongs to the peptidase S53 family. TPP1 is detected in all tissues examined with highest levels in heart and placenta and relatively similar levels in other tissues. TPP1 is lysosomal serine protease with tripeptidyl-peptidase I activity. TPP1 may act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. TPP1 requires substrates with an unsubstituted N-terminus. TPP1 mutations have also been shown to cause neuronal ceroid lipofuscinosis type 2 (CLN2).