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Recombinant Human TSTA3/SDR4E1 Protein (His Tag)
SKU: PKSH032483-50
Recombinant Human TSTA3/SDR4E1 Protein (His Tag)
| SKU # | PKSH032483 |
| Expression Host | E.coli |
Description
| Synonyms | 5-Epimerase-4-Reductase, GDP-4-Keto-6-Deoxy-D-Mannose-3, GDP-L-Fucose Synthase, Protein FX, Red Cell NADP(H)-Binding Protein, SDR4E1, Short-Chain Dehydrogenase/Reductase Family 4E Member 1, TSTA3 |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met 1-Lys321 |
| Accession | Q13630 |
| Calculated Molecular Weight | 37.0 kDa |
| Observed Molecular Weight | 40 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0. |
| Reconstitution | Not Applicable |
Background
GDP-L-Fucose Synthase is a NADP(H)-binding protein. It catalyzes the two-step epimerase and the reductase reactions in GDP-D-mannose metabolism, converting GDP-4-keto-6-D-dexoymannose to GDP-L-fucose. GDP-L-Fucose is the substrate of several fucosyltransferase, involving the expression of mamy glycoconjugates, including blood group ABH antigens and development adhesion antigens. Mutations in the TSTA3 gene may cause leukocyte adhesion deficiency type II.