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Recombinant Human Ube2L6 Protein (His Tag)
SKU: PKSH033324-50
Recombinant Human Ube2L6 Protein (His Tag)
| SKU # | PKSH033324 |
| Expression Host | E.coli |
Description
| Synonyms | RIG-B, Retinoic Acid-Induced Gene B Protein, UBCH8, UBE2L6, UbcH8, Ubiquitin Carrier Protein L6, Ubiquitin-Protein Ligase L6, Ubiquitin/ISG15-Conjugating Enzyme E2 L6 |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met 1-Ser153 |
| Accession | O14933 |
| Calculated Molecular Weight | 18.8 kDa |
| Observed Molecular Weight | 17 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 50mM HEPES, 100mM NaCl, pH 8.0. |
| Reconstitution | Not Applicable |
Background
Ubiquitin/ISG15-Conjugating Enzyme E2 L6 (UBE2L6) is an enzyme member of the E2 ubiquitin-conjugating enzyme family. UBE2L6 plays a same function as UBE2D; it catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. UBE2L6 promotes ubiquitination and subsequent proteasomal degradation of FLT3. It has functions in the E6/E6-AP-induced ubiquitination of p53/TP53.