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Recombinant Human UPRT Protein (His Tag)
SKU: PKSH033196-50
Recombinant Human UPRT Protein (His Tag)
| SKU # | PKSH033196 |
| Expression Host | E.coli |
Description
| Synonyms | FUR1, UPP, UPRT, Uracil phosphoribosyltransferase homolog |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met 1-Asp309 |
| Accession | Q96BW1 |
| Calculated Molecular Weight | 35.9 kDa |
| Observed Molecular Weight | 40 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0. |
| Reconstitution | Not Applicable |
Background
UPRT is a cytoplasmic enzyme which belongs to the UPRTase family. UPRT is highly expressed in leukocytes, liver, spleen and thymus, with lower expression in brain, lung and skeletal muscle. UPRTcatalyzes the conversion of uracil and 5-phosphoribosyl-1-R-diphosphate to uridine monophosphate (UMP). This reaction is an important part of nucleotide metabolism, specifically the pyrimidine salvage pathway. UPRT is a potential target for rational design of drugs to treat parasitic infections and cancer